Stereospecific Inhibition of Cholinesterases by Mefloquine Enantiomers(Medicinal Chemistry,Chemical)

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概要

• 論文の詳細を見る

• Mefloquine enantiomer (+)-1, (-)-1 were found to be stereospecific in their inhiivition of acetylcholinesterase and butyrylcholinesterase, (-)-1 being the more potent inhibitor in both cases. Similar observations were also made with respect to (-)-quinine and (+)-quinidine, which are, configurational analogues of (+)-1 and (-)-1, respectively. A positive synclinical conformation for the "N-C-C-O" segment of metloquine appeared to be necessary for good activity.

• 公益社団法人日本薬学会の論文
• 1987-01-25

著者

• Go Mei

  Department Of Pharmacy National University Of Singapore

• NGIAM Tong

  Department of Pharmacy, National University of Singapore

• Ngiam Tong

  Department Of Pharmacy National University Of Singapore

関連論文

• Study of Synthesis and Cardiovascular Activity of Some Furoxan Derivatives as Potential NO-Donors
• Inhibition of Acetylcholinesterase by Diastereomers of 2-Methylamino-1-phynylpropanol and Their Derivatives
• Stereospecific Inhibition of Cholinesterases by Mefloquine Enantiomers(Medicinal Chemistry,Chemical)
• Hydrophobicity Change on N-Oxidation of Some 4-Aminoquinolines
• Effects of mefloquine on the release of marker enzymes from the rat liver crude lysosomal fraction.

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