Inhibition of Acetylcholinesterase by Diastereomers of 2-Methylamino-1-phynylpropanol and Their Derivatives

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概要

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• The anti-acetylcholinesterase activities of the ephedrine diastereomers and their N-methyl derivatives were correlated to the conformation of the molecules in solution. The stereospecificity exhibited by enantiomers of N-methyl-ψ-ephedrinc was attributed to the predominance of one preferred conformation. The possiblity of predicting the absolute configuration of chiral inhibitors from enzyme inhibitions data is discussed.

• 公益社団法人日本薬学会の論文
• 1989-09-25

著者

• GO Mei

  Department of Pharmacy, National University of Singapore

• Go Mei

  Department Of Pharmacy National University Of Singapore

• NGIAM Tong

  Department of Pharmacy, National University of Singapore

• Ngiam Tong

  Department Of Pharmacy National University Of Singapore

関連論文

• Study of Synthesis and Cardiovascular Activity of Some Furoxan Derivatives as Potential NO-Donors
• Inhibition of Acetylcholinesterase by Diastereomers of 2-Methylamino-1-phynylpropanol and Their Derivatives
• Stereospecific Inhibition of Cholinesterases by Mefloquine Enantiomers(Medicinal Chemistry,Chemical)
• Hydrophobicity Change on N-Oxidation of Some 4-Aminoquinolines
• Effects of mefloquine on the release of marker enzymes from the rat liver crude lysosomal fraction.

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