The Role of Nitric Oxide in Radiation Damage(Pharmacology)

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概要

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• This study investigated the role of nitric oxide in radiation-induced damage by examining changes in mouse serum nitrate concentrations after irradiation. In addition, the contribution of S-2-aminoethylisothiourea 2HBr(AET) to the mechanisms of radiation damage protection was also clarified. The serum nitrate concentration increased as soon as 1.5 h after irradiation, and after 2.5 to 3.0 h the concentrations were significantly higher compared with normal levels. Normal levels were re-established after 12 h. Post-irradiation serum nitrate concentrations increased dose-dependently with irradiation dose (19.6-31.5Gy). AET suppressed increases in the serum nitrate concentration following irradiation while 2-mercaptoethylamine HC1 (MEA) did not. AET has an inhibitory effect on inducible nitric oxide synthase (iNOS); therefore, the increase in nitric oxide after irradiation may be produced by iNOS. Combined administration of irradiation and lipopolysaccharide (LPS) induced a significant increase in serum nitrate concentration, and a significant decrease in survival rate, compared with irradiation alone. The administration of AET or aminoguanidine increased survival rate following irradiation. In contrast to findings after LPS administration, IL-1β and IFN-γ were not determined in serum following irradiation. Existing iNOS is activated by irradiation, and nitric oxide production appears to increase without iNOS induction. Thus, the irradiation-induced increase in nitric oxide may be related to lethal injury.

• 2007-06-01

著者

• MATSUDA Shinji

  Department of Pathology, Kouseiren Takaoka Hospital

• Matsuda Shinji

  Department Of Biology Faculty Of Pharmaceutical Sciences Hoshi University

• OHTA Setsuko

  Department of Biology, Faculty of Pharmaceutical Sciences, Hoshi University

• GUNJI Mihoko

  Department of Radio-Pharmacy, Faculty of Pharmaceutical Sciences, Hoshi University

• KAMOGAWA Asahi

  Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine

• Gunji Mihoko

  Department Of Radio-pharmacy Faculty Of Pharmaceutical Sciences Hoshi University

• Ohta Setsuko

  Department Of Biology Faculty Of Pharmaceutical Sciences Hoshi University

• Kamogawa Asahi

  Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine

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