The Effect of a High-carbohydrate Diet on TNF-α Levels in Response to LPS after Exhausting Exercise in Rats

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概要

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• "Although strenuous prolonged exercise is associated with suppressed immune function, the effect of a carbohydrate diet on this response is unknown. The aim of the present study was to investigate the effects of feeding a high-carbohydrate diet for a week on immune responses after exhaustive exercise. Female F344 rats were divided into four groups: a high-carbohydrate (CHO) diet exercised group, a high-CHO diet non-exercised group, a standard diet exercised group, and a standard diet non-exercised group. Rats were fed each diet for 7 days, and the exercised rats ran then until exhausted on a treadmill. The non-exercised rats were maintained in a sedentary condition. Then, all rats were injected with lipopolysaccharide (LPS; 1 mg/kg, i.v.) immediately after exercise or in the sedentary condition. Fasting plasma glucose in the high-CHO diet rats was significantly higher than in the standard diet rats (191 ± 5 vs. 163 ± 10 mg/dl, p<0.05). However, exhaustive exercise significantly reduced tumor necrosis factor (TNF) -α response to LPS in both diet groups (p<0.05). Also, an exercise-induced high corticosterone concentration was observed in both diet groups (p<0.05). Furthermore, no significant effect of high-CHO diet was found on spontaneous activity, an index of sickness behavior, before and after the exercise and LPS treatment. Taken together, these results indicated that feeding a high-CHO diet for a week does not induce an increased response of TNF-α to LPS challenge after exhaustive exercise."

• 川崎医療福祉大学の論文

著者

• Yano Hiromi

  川崎医療福祉大学健康体育学科

• KITAMURA HIROMI

  和洋女子大学生活科学系運動生理学研究室

• MINATO KUMIKO

  和洋女子大学生活科学系運動生理学研究室

• Minato Kumiko

  Department Of Health And Nutrition Wayo Women's University

• Yano Hiromi"

  Department of Health and Sports Science, Faculty of Health Science and Technology, Kawasaki Universi

• "Kitamura Hiromi

  "Department of Health and Nutrition, Wayo Women's University

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• The Effect of a High-carbohydrate Diet on TNF-α Levels in Response to LPS after Exhausting Exercise in Rats

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