ラット膵ランゲルハンス島におけるA,B,D細胞の生理的細胞相関に関する研究

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In order to understand the physiological role of endogenous insulin, glucagon or somatostatin in islet hormone release, isolated rat pancreatic islets were treated with anti-insulin, anti-glucagon or anti-somatostatin antiserum in the presence of physiological amount of glucose. The following results were obtained. 1. Somatostatin release was unchanged by treatment with anti-insulin antiserum which neutralized insulin released by 3.3, 8.3 and 16.7 mM glucose. However, somatostatin release after treatment with. anti-glucagon antiserum was much reduced at all concentrations of glucose when compared with the release from control serum. Exogenous itsulin (0.11, 1.11 μg/ml) had no effect on somatostatin release, but exogenous glucagon (1, 5μg/ml) resulted in a significant increase. Somatostatin release was stimulated by glucose, but the values were not statistically significant. 2. Insulin release treated with anti-glucagon antiserum was reduced in the presence of 3.3 and 8.3 mM glucose, but no suppressive effect was observed at 16.7mM glucose. Insulin release treated with anti-somatostatin antiserum was much enhanced at 3.3 and 8.3mM glucose but no change was noted at 16.7mM glucose. 3. Glucagon release treated with anti-insulin antiserum was enhanced at 3.3 and 8.3 mM glucose, but the release was unchanged at 16.7 mM glucose. On the other hand, enhanced glucagon release was observed at all concentrations of glucose by treatment with anti-somatostatin antiserum. These results suggest the presence of physiological relationship between A, B and D cells in the modulation of islet hormone release.
神戸大学の論文

ラット膵ランゲルハンス島におけるA,B,D細胞の生理的細胞相関に関する研究

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