Effect of Edaravone, a Free Radical Scavenger, on Ischemia Cerebral Edema Assessed by Magnetic Resonance Imaging
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概要
- 論文の詳細を見る
The anti-edema effect of edaravone, a free radical scavenger, was evaluated by magnetic resonance imaging in six patients with extensive hemispheric ischemic stroke. T_2 relaxation time in the infarct core, the boundary zone of the infarct, and the noninfarcted hemisphere were calculated, and T_2 mapping was performed before and after edaravone administration. Edaravone administration significantly decreased the mean T_2 relaxation time in the boundary zone of the infarct from 121.5 ± 9.2 (mean ± standard deviation) to 114.5 ± 9.9 msec (p=0.008), but not in the core from 142.3 ± 13.4 to 142.2 ± 18.5 msec (p=0.97) or the noninfarcted hemisphere from 93.0 ± 3.7 to 93.1 ± 3.8 msec (p=0.91). The T_2 subtraction map clearly demonstrated shortened T2 relaxation time in the boundary zone of the infarct. The present results indicate that edaravone can salvage the boundary zone of the infarct and is a useful cytoprotective anti-edema agent.
- 社団法人 日本脳神経外科学会の論文
- 2007-05-15
著者
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Katayama Yasuo
Divisions of Neurology, Nephrology, and Rheumatology, Department of Internal Medicine, Nippon Medica
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Katayama Yasuo
Division Of Neurology Nephroiogy And Rheumatology Department Of Internal Medicine Nippon Medical Sch
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Suda Satoshi
Division Of Neurology Nephroiogy And Rheumatology Department Of Internal Medicine Nippon Medical Sch
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Katayama Yasuo
Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University
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IGARASHI Hironaka
Center for Integrated Human Brain Science, Brain Research Institute, Niigata University
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ARAI Yasushi
Division of Neurology, Nephroiogy, and Rheumatology, Department of Internal Medicine, Nippon Medical
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ANDOU Jyun
Department of Radioiogy, Kitamurayama Hospital
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CHISHIKI Tetsuro
Department of Neurosurgery, Kitamurayama Hospital
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Igarashi Hironaka
Center For Integrated Human Brain Science Brain Research Institute Niigata University
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Andou Jyun
Department Of Radioiogy Kitamurayama Hospital
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Arai Yasushi
Division Of Neurology Nephroiogy And Rheumatology Department Of Internal Medicine Nippon Medical Sch
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Chishiki Tetsuro
Department Of Neurosurgery Kitamurayama Hospital
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