Effects of Rosa roxburghii Extract on Proliferation and Differentiation in Human Hepatoma SMMC-7721 Cells and CD34^+ Haematopoietic Cells
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概要
- 論文の詳細を見る
Rosa roxburghii Tratt is an herbal medicine with anticancer potential. This study investigated the effects of an ethanol extracts and a triterpene (CiLi triterpene) of Rosa roxburghii on proliferation and differentiation of human hepatoma SMMC-7721 cells and in umbilical cord blood CD34^+ hematopoietic progenitor cells. The CiLi triterpene and ethanol extracts inhibited the proliferation of hepatoma cells in a concentration- and time-dependent manner and decreased the release of alpha-fetoprotein from hepatoma cells. Apoptosis was increased only at the highest dose of the ethanol extract in hepatoma cells. The Cili triterpene and ethanol extracts of Rosa roxburghii did not affect the differentiation of cord blood CD34^+ cells to granulocytes and monocytes, as evidenced by flow cytometry analysis of CD11b and CD15. Thus the Cili triterpene and ethanol extracts of Rosa roxburghii are effective in the inhibition of human hepatoma SMMC-7721 cell growth, without affecting the differentiation of CD34^+ cells.
- 社団法人日本薬学会の論文
- 2007-02-01
著者
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CHEN Dai
Department of Mechanical Engineering, Tokyo University of Science
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Zhou Qi
Department Of Chemistry Wuhan University
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Zhou Qi
Department Of Pharmacology Chongqing Medical University
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Yu Li
Department of Pharmacology, Zunyi Medical College
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Fang Ning
Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical College
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Yang Xiao
Key Laboratory of Chemistry for Natural Products of the Chinese Academy of Science in Guizhou provin
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Liu Jin
Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical College
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Liu Jia
Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical College
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Liu Liu
Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical College
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Liu Jia
Key Laboratory Of Biodiversity And Conservation Of Aquatic Organisms Institute Of Hydrobiology Chine
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Liu Jia
Key Laboratory Of Cell Engineering In Guizhou Province Affiliated Hospital Of Zunyi Medical College
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Fang Ning
Key Laboratory Of Cell Engineering In Guizhou Province Affiliated Hospital Of Zunyi Medical College
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Chen Dai
Department Of Pharmacology Chongqing Medical University
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Liu Jin
Key Laboratory Of Cell Engineering In Guizhou Province Affiliated Hospital Of Zunyi Medical College
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Yu Li
Department Of Pharmacology Zunyi Medical College:key Laboratory Of Cell Engineering In Guizhou Provi
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Yu Li
Department Of Analytical Chemistry School Of Pharmacy Shenyang Pharmaceutical University
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Yang Xiao
Key Laboratory Of Automobile Materials Ministry Of Education Department Of Materials Science And Engineering Nanling Campus Of Jilin University
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