脱灰骨粉末移植による骨誘導課程に関する電子顕微鏡的研究
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概要
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Coarse powder of acid-insoluble matrix of diaphysis rapidly and invariably transformed fibroblasts into masses of cartilage and bone containing hematopoietic marrow. Electron microscopic studies were performed conventionally and histochemcally on transformation plaques which were formed after subcutaneous allograft at the abdominal wall of Long-Evans Rat. The results were summarized as follows : 1. On day 1, the implanted matrix was surrounded by fibrin clot and polymorphonuclear leukocytes becoming a discrete congromerate. Lysosomal enzyme are speculated to participate in the process of absorbing this matrix and release the bone morphogenetic property from transplanted bone matrix. 2. On day 3, leukocytes started to disappeare, and macrophages gradually take place having fibroblasts as well. Chondrocytes were originated from fibroblastic cell, and macrophages seemed to play an important role on the differentiation of the fibroblastic cells. 3. The lysosomal enzymes within cartilage matrix reduce protein-polysaccaride contents, This change renders collagen or other matrix components more calcifiable. 4. It is likely that matrix vesicles are resulted from the disintegration of the cell processes. 5. Osteoblasts and osteoclastswere observed after the invasion of blood vesseles, It will be suggested that the origin of osteoblasts are perivascular mesenchymal cells, and osteoclasts are formed through cellular fusion among vascular monocytic macrophagic type cells.
- 神戸大学の論文