The Investigation of the Pharmacokinetics of Pulsatile-Release Salbutamol Sulfate with pH-Sensitive Ion Exchange Resin as the Carriers in Beagle Dogs

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概要

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• We previously reported the preparation of the salbutamol sulfate pulsatile-release capsules with the pH-sensitive ion exchange resin as the carriers. In the present study, we investigated the pharmacokinetics of the salbutamol sulfate pulsatile-release capsules in beagle dogs. The analysis method was established for the drugs in vivo by HPLC method. The pharmacokinetics parameters of pulsatile-release salbutamol sulfate and reference tablet were AUC_<0-24>(ng・h/ml) 1031.8±123.1, 1112.6±118.24, C_<max>(ng/ml) 172.4±21.4, 179.3±26.1, T_<max>(h) 3.8±0.6, 1.5±0.5, T_<lag>(h) 2.7±0.5, 0.3±0.2. The results showed that the test dosage forms was bioequivalent with reference dosage form, and had an obviously pulsatile-release effect.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• PAN Weisan

  Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University

• Zhao Xin

  Institute Of Photographic Chemistry Academia Sinica

• Zhao Xin

  Institute For Protein Research Osaka University

• Zhao Xin

  Institute Of Materia Medica Shen Yang No. 1 Pharmaceutical Factory

• Pan Weisan

  中華人民共和国

• Pan Weisan

  Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University

• Liu Hongfei

  Department Of Pharmaceutics Shen Yang Pharmaceutical University:institute Of Materia Medica Shen Yan

• SUN Tianhui

  Department of Pharmaceutics, Shen yang Pharmaceutical University

• YU Feiqian

  Department of Pharmaceutics, Shen yang Pharmaceutical University

• GUO Hong

  Department of Pharmaceutics, Shen yang Pharmaceutical University

• Guo Hong

  Department Of Pharmaceutics Shen Yang Pharmaceutical University

• Yu Feiqian

  Department Of Pharmaceutics Shen Yang Pharmaceutical University

• Sun Tianhui

  Department Of Pharmaceutics Shen Yang Pharmaceutical University

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