Effects of Isopropyl Palmitate on the Skin Permeation of Drugs(Biopharmacy)

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概要

• 論文の詳細を見る

• The model penetrants oxaprozin, nimesulide, gliclazide, and ribavirin, because of their different lipophilicities, were selected to assess the enhancing activity of pre-treatment solutions consisting of isopropyl palmitate (IP) in ethanol (5%, 10%, 15% and 20%, w/w, respectively) across excised rat skin using Franz diffusion cells and HPLC detection. All pre-treatment solutions produced a significant increase in the flux and permeation of all four penetrants (p<0.001) and a relationship between penetrant lipophilicity and enhancement effect was observed. The general order of IP effectiveness at concentration was 20%>15%>10%>5% (w/w). The lag-time of drugs did not significantly change except for ribavirin.

• 公益社団法人日本薬学会の論文
• 2006-11-01

著者

• LI Jizhong

  Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University

• PAN Weisan

  Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University

• Pan Weisan

  Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University

• Pan Weisan

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Li Jizhong

  Department Of Pharmaceutics School Of Pharmacy Shenyang Pharmaceutical University

• Li Jizhong

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• GUO Hong

  Department of Pharmaceutics, Shen yang Pharmaceutical University

• NIE Shufang

  Department of Pharmaceutics, Shen yang Pharmaceutical University

• LIU Zhidong

  Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine

• Liu Zhidong

  Research Center Of Traditional Chinese Medicine Tianjin University Of Traditional Chinese Medicine

• Guo Hong

  Department Of Pharmaceutics Shen Yang Pharmaceutical University

• Guo Hong

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Nie Shufang

  Department Of Pharmaceutics Shenyang Pharmaceutical University

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• Preparation and Characterization of a Novel pH-Sensitive Ion Exchange Resin
• Effects of Isopropyl Palmitate on the Skin Permeation of Drugs(Biopharmacy)
• The Permeation of Nalmefene Hydrochloride across Different Regions of Ovine Nasal Mucosa

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