Resveratrol Attenuates Ischemia-Reperfusion-Induced Leukocyte-Endothelial Cell Adhesive Interactions and Prolongs Allograft Survival Across the MHC Barrier

スポンサーリンク

概要

• 論文の詳細を見る

• Background Ischemic-reperfusion(IR) injury is a multifactorial process that leads to tissue damage and rejection in composite tissue allotransplantation(CTA). Antioxidant or free radical scavenger may reduce IR injury, so the effects of resveratrol, a natural antioxidant, on amelioration of leukocyte-endothelial cell adhesive interaction and prevention of transplant rejection in CTA were investigated. Methods and Results In a microcirculatory study, resveratrol significantly reduced the number of IR-induced leukocytes rolling, adhering, and transmigrating in the postcapillary venules of the cremaster muscle. In the CTA study using groin skin flap allotransplantation across the MHC barrier 8-11-week-old Brown Norway donors(RT1^n) and 10-11-week-old Lewis recipients(RT1^l) rats were randomized into 4 groups: isograft control, allograft control, and 2 groups that received different doses of resveratrol(0.1 or 0.5mg/kg) for 7 days. Allograft control animals rejected their allograft between 5 and 7 days postoperatively, whereas resveratrol-treated recipients had a moderate survival prolongation compared with the allograft control group. Consistent with these observations, histology results also showed reduction of lymphocytic infiltration and necrosis in resveratroltreated subjects. Conclusion Resveratrol treatment prolonged groin skin flap allotransplant survival in the recipient and ameliorated the leukocyte-endothelial cell adhesive interactions that may lead to attenuated and delayed rejection in CTA.

• 社団法人日本循環器学会の論文
• 2007-02-20

著者

• Hung Li-man

  Department Of Life Science College Of Medicine Chang Gang University

• Hsieh Yu-Hsuan

  Department of Life Science, College of Medicine, Chang Gang University

• Huang Shiang-Suo

  Department of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical Univer

• Wei Fu-Chan

  Department of Plastic & Reconstructive Surgery, ChangGung Memorial Hospital

• Huang Shiang-suo

  Department Of Pharmacology And Institute Of Medicine College Of Medicine Chung Shan Medical Universi

• Wei Fu-chan

  Department Of Plastic & Reconstructive Surgery Changgung Memorial Hospital

• Huang Shiang-suo

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

• Hsieh Yu-hsuan

  Department Of Life Science College Of Medicine Chang Gang University

関連論文

• Resveratrol Attenuates Ischemia-Reperfusion-Induced Leukocyte-Endothelial Cell Adhesive Interactions and Prolongs Allograft Survival Across the MHC Barrier
• Ischemic Preconditioning Attenuates Postischemic Leukocyte-Endothelial Cell Interactions : Role of Nitric Oxide and Protein Kinase C
• Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats
• Metacarpal Hand : Classification and Guidelines for Microsurgical Reconstruction with Toe Transfers

スポンサーリンク