Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

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概要

• 論文の詳細を見る

• Background: Antioxidants effectively reduce ischemia-reperfusion (IR) injury. The cardioprotective effects of luteolin, a flavonoid that exhibits antioxidant properties and is widely available in many fruits and vegetables, were examined in rats subjected to myocardial IR injury. Methods and Results: Rats were subjected to myocardial ischemia or reperfusion injury to evaluate the antiarrhythmic effects of luteolin. Myocardial infarct size was determined histochemically with triphenyltetrazolium chloride staining of the left ventricle. Luteolin was administered intravenously 15min before occlusion of the coronary artery. The incidence and duration of ventricular tachycardia and ventricular fibrillation and mortality during myocardial ischemia were significantly reduced by luteolin (10μg/kg). Similarly, luteolin (1μg/kg) reduced ventricular arrhythmias and mortality during the reperfusion phase. Pretreatment with luteolin decreased plasma lactate dehydrogenase and nitric oxide (NO) levels. Luteolin (10μg/kg) significantly reduced the myocardial infarct size, as well as malondialdehyde production in tissue samples of myocardial IR injury. Luteolin also downregulated inducible NO synthase protein and mRNA expression, but did not significantly alter neuronal NO synthase or endothelial NO synthase expression. Conclusions: Luteolin is capable of protecting the myocardium against IR injury. The actions of luteolin are at least partly mediated through downregulation of NO production and its own antioxidant properties. (Circ J 2011; 75: 443-450)

• 2011-01-25

著者

• Hung Li-man

  Department Of Life Science College Of Medicine Chang Gang University

• Huang Shiang-Suo

  Department of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical Univer

• Huang Shiang-suo

  Department Of Pharmacology And Institute Of Medicine College Of Medicine Chung Shan Medical Universi

• Zhang Friedrich

  Department Of Urology Mackay Memorial Hospital

• Lin Ruey-hseng

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

• Hung Li-man

  Department Of Life Science College Of Medicine Chang Gung University

• LIAO Pei-Hu

  Department of Pharmacology and Institute of Medicine, Chung Shan Medical University and Department o

• CHEN Yi-Hung

  Graduate Institute of Acupuncture Science, China Medical University

• KUAN Yu-Hsiang

  Department of Pharmacology and Institute of Medicine, Chung Shan Medical University and Department o

• SHIH Hung-Che

  Department of Pharmacology and Institute of Medicine, Chung Shan Medical University and Department o

• TSAI Shen-Kou

  Division of Anesthesiology, Cheng-Hsin General Hospital

• Liao Pei-hu

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

• Tsai Shen-kou

  Division Of Anesthesiology Cheng-hsin General Hospital

• Chen Yi-hung

  Graduate Institute Of Acupuncture Science China Medical University

• Shih Hung-che

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

• Kuan Yu-hsiang

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

• Huang Shiang-suo

  Department Of Pharmacology And Institute Of Medicine Chung Shan Medical University And Department Of

関連論文

• Resveratrol Attenuates Ischemia-Reperfusion-Induced Leukocyte-Endothelial Cell Adhesive Interactions and Prolongs Allograft Survival Across the MHC Barrier
• Ischemic Preconditioning Attenuates Postischemic Leukocyte-Endothelial Cell Interactions : Role of Nitric Oxide and Protein Kinase C
• Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

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