Food constituents enhance urease activity in Helicobacter pylori

概要

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Urease activity of Helicobacter pylori recovered from the stomach of H. pylori-infected Mongolian gerbils was affected by the diet used after infection. The effect of dietary components on urease activity was investigated by growth of H.pylori in Brucella broth with the addition of calcium, collagenpeptide and proline. Urease activity was about 10 times higher after growth of H. pylori in the presence of collagenpeptide. The activity of urease gene cluster components was measured in cell-free extracts of transformed E.coli DH5a cultured in the presence of calcium, collagenpeptide and proline. UreA activity was not affected whereas ureI promoter activity increased on the addition of collagenpeptide or proline to the medium. Due to the important role of urease in infection by H.pylori these results suggest the possibility that diet may influence the appearance of symptoms in H.pylori infected Mongolian gerbils.
山口県立大学の論文
2006-03-25