Molecular Architecture of the Sperm Flagella : Molecules for Motility and Signaling
スポンサーリンク
概要
- 論文の詳細を見る
Sperm motility is generated by a highly organized, microtubule-based structure, called the axoneme, which is constructed from approximately 250 proteins. Recent studies have revealed the molecular structures and functions of a number of axonemal components, including the motor molecules, the dyneins, and regulatory substructures, such as radial spoke, central pair, and other accessory structures. The force for flagellar movement is exerted by the sliding of outer-doublet microtubules driven by the molecular motors, the dyneins. Dynein activity is regulated by the radial spoke/central pair apparatus through protein phosphorylation, resulting in flagellar bend propagation. Prior to fertilization, sperm exhibit dramatic motility changes, such as initiation and activation of motility and chemotaxis toward the egg. These changes are triggered by changes in the extracellular ionic environment and substances released from the female reproductive tract or egg. After reception of these extracellular signals by specific ion channels or receptors in the sperm cells, intracellular signals are switched on through tyrosine protein phosphorylation, Ca^<2+>, and cyclic nucleotide-dependent pathways. All these signaling molecules are closely arranged in each sperm flagellum, leading to efficient activation of motility.
- 社団法人日本動物学会の論文
- 2003-09-25
著者
-
Inaba Kazuo
Asamushi Marine Biological Station Faculty Of Science Tohoku University
-
Inaba K
Shimoda Marine Research Center University Of Tsukuba
関連論文
- PROTEOMIC ANALYSIS OF MOTILITY ACTIVATION IN CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- CALAXIN: A NOVEL CA2+ -BINDING PROTEIN LOCALIZED ON THE OUTER ARM DYNEIN IN SPERM FLAGELLA OF CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- IMMUNOFLUORESCENCE ANALYSIS OF SPERM PROTEINS THAT CHANGES AT ACTIVATION IN THE ASCIDIAN CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- CHANGES OF RADIAL SPOKE PROTEIN LRR37 COUPLED WITH THE ACTIVATION OF SPERM MOTILITY IN CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- 14-3-3 PROTEIN IS INVOLVED IN THE ACTIVATION OF SPERM MOTILITY IN THE ASCIDIAN CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Conformational Changes of Dynein : Mapping and Sequence Analysis of ATP/Vanadate-Dependent Trypsin-Sensitive Sites on the Outer Arm Dynein β Heavy Chain from Sea Urchin Sperm Flagella
- ISOLATION OF AN INNER ARM DYNEIN INTERMEDIATE CHAIN IC116 FROM CIONA INTESTINALIS AND ITS ROLES IN FLAGELLAR MOTILITY(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Genetic Relationships of the Genus Tridentiger (Pisces, Gobiidae) Based on Allozyme Polymorphism
- IDENTIFICATION AND CHARACTERIZATION OF CMUB116 AND NDK/DPY26 AS NOVEL COMPONENTS OF FLAGELLAR RADIAL SPOKES IN THE SPERM OF CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Societ
- IDENTIFICATION OF AXONEMAL COMPONENTS ASSOCIATED WITH RADIAL SPOKE PROTEIN 3 (RSP3) FROM SPERM OF THE ASCIDIAN CIONA INTESTINALIS(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Molecular Architecture of the Sperm Flagella : Molecules for Motility and Signaling
- Transmembrane Cell Signaling for the Initiation of Trout Sperm Motility : Roles of Ion Channels and Membrane Hyperpolarization for Cyclic AMP Synthesis(Reproductive Biology)
- ISOLATION AND CHARACTERIZATION OF AXONEMAL RADIAL SPOKE COMPONENTS FROM SPERM FRAGELLA OF THE ASCIDIAN CIONA INTESTINALIS(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Ap58 : A NOVEL PROTEIN BINDING TO IN SITU OUTER ARM DYNEIN(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Purification and identification of 26kDa axonemal phosphoprotein regulating SAAF-induced sperm activation in ascidian, Ciona intestinalis(Cell Biology and Morphology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- Cyclic AMP-and calmodulin-dependent phosphorylation of 21 and 26 kDa proteins in axoneme is a prerequisite for SAAF-induced motile activation in ascidian spermatozoa
- SMOAC: SPERM MOTILITY ACTIVATING COMPLEX PRODUCED BY TCTEX-RELATED LC1 AND LC3 FROM SEA URCHIN SPERM OUTER ARM DYNEIN(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)