ポリアミンの調節と癌
スポンサーリンク
概要
- 論文の詳細を見る
This review describes my work in the field of polyamine research for the last 35 years. My research started with developing the improved synthesis of decarboxylated S-adenosylmethionine and then moved to the purification of spermidine synthase from rat prostate. I also took considerable efforts to find the synthetic procedure for various polyamines with high yield in order to prepare ^<15>N-labeled polyamines. On the basis of these methodological work, I searched for the inhibitor of spermidine synthase and found trans-4-methylcyclohexylamine (MCHA), the most effective one at the present time. I also developed a new analytical method for polyamines using stable isotope and ionspray ionization mass spectrometry (IS-MS). Based on these studies I examined the role of polyamines in liver regeneration and found that oral administration of MCHA effectively changed the concentration of polyamines and inhibited the hepatic growth. I also found the close relationship between the concentration ratio of spermidine to spermine and the extent of liver regeneration. These results may shed new light on the control of cell growth by polyamine in vivo.
- 2006-08-01
著者
関連論文
- Syntheses of [13C, 15N]-Labeled Polyamines
- Measurements of Macromolecule-Bound and Ultra-FiltrablePolyamines in Rat Liver Homogenized without Buffer
- Preparation and Usefulness of Some Fluorogenic Substrates for Assay of Arginyl-tRNA-Protein Transferase byHPLC
- p-アミノアゾベンゼン誘導体の薄層クロマトグラフィー
- Primary Structure of Rat Spermidine Synthase: AnExample of Refining the cDNA-Derived Amino AcidSequence
- Occurrence of aminopropylhomospermidine as themajor cellular polyamine in a halophilic, phototrophicalpha proteobacterium, Rhodothalassium salexigens
- Occurrence of tertiary branched tetraamines in two aquaticplants
- ポリアミンの調節と癌
- Arginyl-tRNA-Protein Transferase Activities in CrudeSupernatants of Rat Tissues
- ポリアミンの調節を目指した方法論の開発