Scalable Synthesis of (+)-2-Amino-3-fluorobicyclo [3.1.0] hexane-2,6-dicarboxylic Acid as a Potent and Selective Group II Metabotropic Glutamate Receptor Agonist

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概要

• 論文の詳細を見る

• We successfully synthesized the potent and selective group II mGluR agonist (+)-1 (MGS0008) via a process incorporating the key step of efficient fluorination of epoxide (±)-5c. This method would be adaptable to largescale synthesis to produce (+)-1 in multi-gram quantities.

• 公益社団法人日本薬学会の論文
• 2007-01-01

著者

• Taguchi Takeo

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• SAKAGAMI Kazunari

  Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.

• KUMAGAI Toshihito

  Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.

• NAKAZATO Atsuro

  Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.

• Sakagami Kazunari

  Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Nakazato Atsuro

  Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Kumagai Toshihito

  Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.

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• Scalable Synthesis of (+)-2-Amino-3-fluorobicyclo [3.1.0] hexane-2,6-dicarboxylic Acid as a Potent and Selective Group II Metabotropic Glutamate Receptor Agonist

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