Evaluation of Oxidative Damage Induced by Natural Sunlight in Drosophila
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概要
- 論文の詳細を見る
The sunlight that reaches the surface of the earth is composed of polychromatic light with wavelengths ranging from 290nm to 2500nm. Ultraviolet (UV) light is a component of sunlight that is harmful to organisms. Although it is known that sunlight induces photoproducts and harmful effects such as major DNA damage caused by UV light in the tissues of many species including human skin, it is not clear whether sunlight induces oxidative damage in organisms. In this study, we investigated whether sunlight causes oxidative damage in exposed organisms using Drosophila. Third instar larvae were exposed to sunlight for an evaluation of viability and 8-hydroxydeoxyguanosine (8-OHdG) content. Urate-null Drosophila mutant larvae (ry^<506>), which are sensitive to active oxygen-producing agents, were more sensitive to sunlight lethality than the wild-type strain under limited conditions. This sunlight-induced toxicity in ry^<506> larvae was partially prevented by pretreatment of larvae with 400mM uric acid. The level of 8-OHdG in DNA showed no significant increase in both strains. In contrast, sunlight was significantly mutagenic for all seasons as reported previously. These results suggest that sunlight is partly responsible for oxidative damage in Drosophila and that 8-OHdG-formation plays little or no role in sunlight-induced mutation and toxicity.
- 日本環境変異原学会の論文
- 2006-11-30
著者
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KASAI HIROSHI
Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
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Hayashi Hiroe
Faculty Of Pharmaceutical Sciences Okayama University
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Kasai Hiroshi
Institute Of Industrial Ecological Sciences Department Of Environmental Oncology University Of Occup
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Kasai Hiroshi
Institute Of Industrial Ecological Sciences University Of Occupational And Environmental Health
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NEGISHI Tomoe
Faculty of Pharmaceutical Sciences, Okayama University
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Negishi Tomoe
Faculty Of Pharmaceutical Sciences Okayama University:faculty Of Pharmaceutical Sciences Okayama Uni
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Negishi Tomoe
Faculty Of Pharmaceutical Sciences Okayama University
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Arakawa Ritsuo
Faculty of Pharmaceutical Sciences, Okayama University
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Terao Mie
Faculty of Pharmaceutical Sciences, Okayama University
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Arakawa Ritsuo
Faculty Of Pharmaceutical Sciences Okayama University
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Terao Mie
Faculty Of Pharmaceutical Sciences Okayama University
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