Evaluation of the Antineoplastic Activity of Guduchi (Tinospora cordifolia) in Ehrlich Ascites Carcinoma Bearing Mice(Pharmacology)

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概要

• 論文の詳細を見る

• The anticancer activity of dichloromethane extract of guduchi [Tinospora cordifolia (WILLD.) MIERS ex HOOK. F. & THOMS. Family: Menispermaceae (TCE)] in the mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated. The EAC mice receiving 25, 30, 40, 50 and 100 mg/kg, TCE showed a dose dependent elevation in tumor-free survival and a highest number of survivors were observed at 50 mg/kg TCE, which was considered as an optimum dose for its neoplastic action. The average survival time (AST) and median survival time (MST) for this dose were approximately 56 and 55 d, respectively when compared with 19 d of non-drug treated controls. Administration of 50 mg/kg TCE resulted in 100% long-term survivors (up to 90 d). An attempt was also made to evaluate the effectiveness of TCE in the various stages of tumor development, where 50 mg/kg TCE was administered intraperitoneally after 1, 3, 6, 9, 12 or 15 d of tumor inoculation and these days have been arbitrarily designated as stage I, II, III, IV or V, respectively for reasons of clarity. The greatest anticancer activity was recorded for stage I, II and III where number of long term survivors (LTS) was approximately 33, 25 and 17%, respectively. However, treatment of mice at stage IV and V did not increase LTS, despite an increase in AST and MST. The EAC mice receiving 50 mg/kg TCE showed a time dependent depletion in the glutathione (GSH) activity up to 12h post-treatment and marginal elevation thereafter. This depletion in GSH was accompanied by a drastic elevation in lipid peroxidation (LPx) and a maximum elevation in LPx was observed at 6h that declined gradually thereafter. TCE exerted cytotoxic effect on tumor cells by reducing the GSH concentration and increase in LPx simultaneously.

• 公益社団法人日本薬学会の論文
• 2006-03-01

著者

• JAGETIA Ganesh

  Department of Radiobiology, Kasturba Medical College

• Jagetia Ganesh

  Department Of Radiobiology Kasturba Medical College

• RAO Shaival

  Department of Radiobiology, Kasturba Medical College

• Rao Shaival

  Department Of Radiobiology Kasturba Medical College

関連論文

• Influence of Seed Extract of Syzygium Cumini (Jamun) on Mice Exposed to Different Doses of γ-radiation
• Evaluation of the Antineoplastic Activity of Guduchi (Tinospora cordifolia) in Ehrlich Ascites Carcinoma Bearing Mice(Pharmacology)
• Aegle marmelos (L.) CORREA Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice(Pharmacology)
• Enhancement of Radiation Effect by Aphanamixis polystachya in Mice Transplanted with Ehrlich Ascites Carcinoma(Pharmacology)

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