Enhancement of Radiation Effect by Aphanamixis polystachya in Mice Transplanted with Ehrlich Ascites Carcinoma(Pharmacology)

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概要

• 論文の詳細を見る

• The effect of radiation on tumor tissue can be optimized by adding radiosensitizing agents, in order to achieve a greater degree of tumor damage than expected from the use of either treatment alone. The ethanolic extract of Aphanamixis polystachya (APE) was tested in Swiss albino mice transplanted with Ehrlich ascites carcinoma (EAC) and exposed to various doses of γ-radiation. EAC mice received 0, 10, 25, 50, 75, 100, 150 or 200 mg/kg body wt APE before exposure to 6 Gy γ-radiation followed by once daily administration for another 8 consecutive days post-irradiation. The optimum radiosensitizing dose was found to be 50 mg/kg APE that was further tested in EAC mice exposed to 0, 1, 2, 4, 6 or 8 Gy hemi body γ-radiation. The best effect of APE and radiation was observed for 6 Gy γ-radiation. The splitting of 50 mg into two equal fractions of 25 mg and administering the split dose with a gap of 8 h on 1, 3, 5, 7 or 9 d of tumor inoculation resulted in an increased survival even when the drug was administered at late stages (day 5) of tumor development. The APE treatment before irradiation elevated lipid peroxidation followed by a reduction in the glutathione contents. Treatment of tumor bearing mice with APE before irradiation further reduced the activities of various antioxidant enzymes like glutathione peroxidase, glutathione-s-transferase, superoxide dismutase and catalase at different post last drug administration (PLDA) times.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• JAGETIA Ganesh

  Department of Radiobiology, Kasturba Medical College

• Jagetia Ganesh

  Department Of Radiobiology Kasturba Medical College

• Venkatesha Venkatasubbaiah

  Department Of Radiobiology Kasturba Medical College

関連論文

• Influence of Seed Extract of Syzygium Cumini (Jamun) on Mice Exposed to Different Doses of γ-radiation
• Evaluation of the Antineoplastic Activity of Guduchi (Tinospora cordifolia) in Ehrlich Ascites Carcinoma Bearing Mice(Pharmacology)
• Aegle marmelos (L.) CORREA Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice(Pharmacology)
• Enhancement of Radiation Effect by Aphanamixis polystachya in Mice Transplanted with Ehrlich Ascites Carcinoma(Pharmacology)

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