DNA Strand Scission by Mitoxantrone and Binding of Anti-Cancer Quinones to Chromatin DNA

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概要

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• The λ phage DNA and hog thyroid DNA after exposure to a hydroxyl radical-generating system containing NADPH-cytochrome P-450 reductase and anthraquinones such as mitoxantrone (CL 232315) and CL 232468 lacked in intact DNA fragments, indicating DNA strand breaks. The mechanism of DNA scission by the drugs closely resembles that induced by adriamycin and mitomycin C. When isolated hog thyroid chromatin was exposed to the system containing mitoxantrone, fragmentation of chromatin DNA was not detected. DNase I digestion for chromatin DNA was inhibited by the presence of the anthraquinones, suggesting intercalation of the drugs to DNase I-sensitive DNA regions in chromatin without DNA strand breaks.

• 群馬大学の論文
• 1995-03-31

著者

• Hamana Koei

  College Of Medical Care And Technology Gunma University

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