劇症肝炎患者結漿中に見出されたヒト肝細胞増殖因子(hHGF)

概要

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We found the existence of a hepatotrophic factor in plasma or sera of patients with fulminant hepatic failure, and have recently purified a hepatocyte growth-promoting factor, human hepatocyte growth factor (hHGF) from the plasma obtained during the plasma exchange therapy of the patients. The hHGF level in plasma changed parallel with the coma grade of the patients, and it rapidly decreased to almost the normal level when the patient recovered from the disease. Thus, the plasma hHGF level seems to be the result of a self-defense mechanism and hHGF may be a physiological hepatotrophic factor for human liver regeneration. In this review, we summarized our recent papers on hHGF including purification and characterization of hHGF, amino acid sequence of hHGF deduced from its cDNA sequence and plasma levels of hHGF in patients with liver diseases determined by an enzyme-linked immunosorbent assay using polyclonal and monoclonal antibodies against hHGF. Because the amino acid sequence of hHGF has high homology to some serum proteins involved in blood coagulation and fibrinolysis such as plasminogen, we also discussed and predicted the secondary structure of hHGF from that of human plasminogen.
鹿児島大学の論文
1990-03-26