Antioxidant Property of Triphala on Cold Stress Induced Oxidative Stress in Experimental Rats

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概要

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• Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the antioxidant properties of Triphala (Terminalia chebula, Terminalia bellerica and Emblica officinalis) during cold-stress. Four groups of albino rats were employed namely control, Triphala, cold-stress and Triphala with cold-stress. The oxidative stress was assessed by measuring the lipid peroxidation (LPO), enzymatic superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymatic (Vitamin C) antioxidant status in adrenal tissue and plasma corticosterone level. Following cold-exposure (8℃ for 16hr/d/15 days), enzymatic and nonenzymatic antioxidants were significantly reduced with concomitant increase in LPO and corticosterone levels were observed. Administration of Triphala (1g/kg/body weight/48 days) significantly prevents the cold-stress-induced oxidative stress and elevation in LPO and corticosterone levels. This study concludes that Triphala supplementation significantly prevents the cold-stress-induced oxidative stress may due to its antioxidant properties.

• 公益社団法人日本薬学会の論文
• 2006-12-01

著者

• Devi Rathinasamy

  Department Of Physiology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras

• Dhanalakshmi Selvakumar

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras

• Srikumar Ramasundaram

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras Taram

• Manikandan Sundaramahalingam

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras Taram

• Parthasarathy Narayanaperumal

  Department of Physiology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Ta

• Parthasarathy Narayanaperumal

  Department of Physiology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Taramani Campus

関連論文

• Hypolipidemic Effect of Triphala in Experimentally Induced Hypercholesteremic Rats
• Protective Effect of Triphala on Cold Stress-induced Behavioral and Biochemical Abnormalities in Rats
• Antioxidant Property of Triphala on Cold Stress Induced Oxidative Stress in Experimental Rats
• Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat(Pharmacology)
• Immunomodulatory Activity of Triphala on Neutrophil Functions(Pharmacology)

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