Immunomodulatory Activity of Triphala on Neutrophil Functions(Pharmacology)

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概要

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• Immune activation is an effective as well as protective approach against emerging infectious diseases. The immunomodulatory activities of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) were assessed by testing the various neutrophil functions like adherence, phagocytosis (phagocytic index (P.I) and avidity index (A.I)) and nitro blue tetrazolium (NBT) reduction in albino rats. In recent years much attention is being focused on the immunological changes occur during stress. Noise (100dB) stress for 4h/d for 15d, was employed to alter the neutrophil functions. The neutrophil function tests and corticosterone levels were carried out in eight different groups of animals, namely control, Triphala, noise-stress, Triphala noise-stress, and corresponding immunized groups were used. Sheep red blood cells (SRBC 5×10^9 cells per ml) were used for immunizing the animals that belongs to immunized groups. In Triphala administration (1g/kg/d for 48d), A.I was found to be significantly enhanced in the Triphala group, while the remaining neutrophil functions and steroid levels were not altered significantly. However the neutrophil functions were significantly enhanced in the Triphala immunized group with a significant decrease in corticosterone level was observed. Upon exposure to the noise-stress, the neutrophil functions were significantly suppressed and followed by a significant increase in the corticosterone levels were observed in both the noise-stress and the noise-stress immunized groups. These noise-stress-induced changes were significantly prevented by Triphala administration in both the Triphala noise-stress and the Triphala noise-stress immunized groups. Hence our study has divulged that oral administration of Triphala appears to stimulate the neutrophil functions in the immunized rats and stress induced suppression in the neutrophil functions were significantly prevented by Triphala.

• 公益社団法人日本薬学会の論文
• 2005-08-01

著者

• Sheela Devi

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras Taram

• Jeya Parthasarathy

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras Taram

• Srikumar Ramasundaram

  Department Of Physiology Dr. Alm. Pg. Institute Of Basic Medical Sciences University Of Madras Taram

関連論文

• Hypolipidemic Effect of Triphala in Experimentally Induced Hypercholesteremic Rats
• Noise-Stress-Induced Brain Neurotransmitter Changes and the Effect of Ocimum sanctum (Linn) Treatment in Albino Rats
• Protective Effect of Triphala on Cold Stress-induced Behavioral and Biochemical Abnormalities in Rats
• Antioxidant Property of Triphala on Cold Stress Induced Oxidative Stress in Experimental Rats
• Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat(Pharmacology)
• Immunomodulatory Activity of Triphala on Neutrophil Functions(Pharmacology)

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