抗酸化機能と遺伝子制御機能の接点

概要

論文の詳細を見る
Some compounds show a cytoprotective function via gene expreeion as well as antioxidant activities. To define the chemical structure owing antioxidant activity and/or gene expression is important. The present study was conducted to evaluate antioxidant activities of some of ginger constituents and their synthetic derivatives (twenty compounds) possessing a variety of pharmaceutical effects and to find out novel functions of these compounds in cell. All phenolic compounds in ginger inhibited lipid peroxidation of methyl linoleate and low density lipoprotein (LDL). A haydrophilic group at the end of side chain decreased antioxidant activity in LDL. The compounds with longer side chain showed stronger antioxidant activity. A global stydy of gene expression using DNA microarray in endothelial cell exposed to ginger-related compounds revealed that compounds having α-, β-undaturated carbonyl, eg. shogalo, strongly induced expression of genes which were regulated by keap-1/Nrf2/ARE pathway. The side chain effects on gene expression was not as large as observed in antioxidant activity. Nrf2-regulated genes encode cytoprotective proteins against oxidative stress, which may explain a part of pharmaceutical effects of ginger extract.
日本ビタミン学会の論文
2006-10-25