Protective Effects of Tea Melanin against 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity : Antioxidant Activity and Aryl Hydrocarbon Receptor Suppressive Effect(Miscellaneous)

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概要

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• We examined the protective ability of tea melanin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity in C57BL6J mice. Reduced tea melanin (RTM) and non-reduced tea melanin (NRTM) were incorporated to distinguish anti-oxidant activity from alternative pathways. The mice were given a single oral dose of TCDD (100μg/kg body weight) and then they were administered daily with NRTM or RTM (40mg/kg, p.o.) for next 14d. RTM protected the animals against TCDD-induced lipid peroxidation, inhibition of glutathione peroxidase, alteration in reduced and oxidized glutathione concentrations, loss of body weight, and increased relative liver weight. NRTM was less effective as compared to RTM because of its inferior antioxidant activity, but it still displayed a strong protective effect against TCDD toxicity owing to its similar suppression of the activity of the aryl hydrocarbon receptor. Both NRTM and RTM suppressed the expression of CYP1A1 gene and prevented the activation of cytochrome P450 isozyme in the livers of animals exposed to TCDD. These results suggest that tea melanin might be a potential agent offering dual protection against the development of TCDD-induced oxidative stress.

• 公益社団法人日本薬学会の論文
• 2006-11-01

著者

• HUNG Yao-Ching

  Department of Obstetrics and Gynecology, China Medical University Hospital

• Hung Yao-ching

  Graduate Institute Of Biotechnology Hung Kung University And Kung Tien General Hospital

• Hong Meng-yen

  Institute Of Nanotechnology National Chiao Yung University

• Hong Meng-yen

  Institute Of Nanotechnology National Chiao Tung University

• HUANG Guewha

  Institute of Nanotechnology, National Chiao Yung University

• SAVA Vasyl

  Odessa Regional Psychiatric Hospital No. 1

• BLAGODARSKY Vyacheslav

  Odessa Regional Psychiatric Hospital No. 1

• Huang Guewha

  Institute Of Nanotechnology National Chiao Yung University

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