Dykellic Acid Inhibits Cell Migration and Tube Formation by RhoA-GTP Expression(Biopharmacy)

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概要

• 論文の詳細を見る

• Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and anti-angiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.

• 社団法人日本薬学会の論文
• 2006-11-01

著者

• LEE Ho-Jae

  Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Kim Sung-uk

  Korea Research Institute Of Bioscience & Biotechnology

• Lee Sang-han

  Department Of Food Science & Technology Kyungpook National University

• HEO Jin-Chul

  Department of Food Science & Technology, Kyungpook National University

• PARK Ja-Young

  Department of Food Science & Technology, Kyungpook National University

• WOO Sang-Uk

  Department of Food Science & Technology, Kyungpook National University

• RHO Jae-Rang

  Department of Bioscience & Biotechnology, Chungnam National University

• KHO Yung-Hee

  Korea Research Institute of Bioscience & Biotechnology

• Heo Jin-chul

  Department Of Food Science & Technology Kyungpook National University

• Lee Ho-jae

  Korea Research Institute Of Bioscience & Biotechnology

• Woo Sang-uk

  Department Of Food Science & Technology Kyungpook National University

• Kho Yung-hee

  Korea Research Institute Of Bioscience & Biotechnology

• Rho Jae-rang

  Department Of Bioscience & Biotechnology Chungnam National University

• Park Ja-young

  Department Of Food Science & Technology Kyungpook National University

• Lee Sang-Han

  Department of Food Science & Biotechnology, Kyungpook National University

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• Dykellic Acid Inhibits Cell Migration and Tube Formation by RhoA-GTP Expression(Biopharmacy)
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