Photochemistry of Desonide, a Non-fluorinated Steroidal Anti-inflammatory Drug

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概要

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• The photochemistry of anti-inflammatory drug desonide (De, 1) was studied in aerobic as well as in anaerobic condition with different irradiation wavelengths (254, 310nm) in acetonitrile and 2-propanol. All photoproducts obtained were isolated and characterized on the basis of IR, ^1H-, ^<13>C-NMR spectroscopy and elemental analysis study. The products were: 11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5-cyclopregn-3-ene-2,20-dione 2 (254nm), 11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-diene-3-one 3 (310nm/2-propanol), 17β-hydroperoxy-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-diene-3-one 4 (310nm/O_2/2-propanol). Cyclohexadienone moiety in ring A and keto group at C_<17> were found to be deeply modified by UV light therefore, loss of biological activity both during storage and in vivo can not be ruled out.

• 公益社団法人日本薬学会の論文
• 2006-06-01

著者

• Husain Adil

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

• Iqbal Jawaid

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

• GUPTA Anamika

  Department of Chemistry, Organic Chemistry Section, Aligarh Muslim University

• Gupta Anamika

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

関連論文

• Photochemistry of Desonide, a Non-fluorinated Steroidal Anti-inflammatory Drug
• Photooxidation of Acyclovir with Thermally Generated Triplet Excited Ketones. A Comparison with Type I and II Photosensitizers

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