Photooxidation of Acyclovir with Thermally Generated Triplet Excited Ketones. A Comparison with Type I and II Photosensitizers

スポンサーリンク

概要

• 論文の詳細を見る

• The antiviral drug acyclovir (Ac, 1) was treated with triplet excited ketones, which have been generated in thermal decomposition of 3-(hydroxymethyl)-3, 4, 4-trimethyl-1, 2-dioxetane (HTMD), in the dark. Three major oxidation products were detected by means of spectroscopic measurements. The products were (2-hydroxy-ethoxy) methyl spiroiminodihydantoin (2), (2-hydroxyethoxy) methyl (amino)-2-imino-1, 2-dihydroimidazole-5-one (3), and 2, 2-diamino-4-[(2-hydroxyethoxy) methyl) amino)-5-[2H]-oxazolone (4). Equal amounts of type I and type II photooxidation products were found, as could be established by comparison with predominant type I (riboflavin) and type II (rose bengal) photosensitizers. The concentration and time profiles for the HTMD-induced oxidation of Ac were also determined. The participation of singlet oxygen in HTMD-induced oxidation was confirmed by the substantial D_2O effect in the formation of spiroiminodihydantoin (2).

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Husain Adil

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

• Iqbal Jawaid

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

• GUPTA Anamika

  Department of Chemistry, Organic Chemistry Section, Aligarh Muslim University

• Gupta Anamika

  Department Of Chemistry Organic Chemistry Section Aligarh Muslim University

関連論文

• Photochemistry of Desonide, a Non-fluorinated Steroidal Anti-inflammatory Drug
• Photooxidation of Acyclovir with Thermally Generated Triplet Excited Ketones. A Comparison with Type I and II Photosensitizers

スポンサーリンク