<Originals>Relationship of Muscle Strength with Dehydroepiandrosterone Sulfate(DHEAS),Testosterone and Insulin-like Growth Factor-I in Male and Female Athletes

概要

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The current study was designed to examine the association of leg extensor power with serum dehydroepiandrosterone sulfate (DHEAS), testosterone and insulin like growth factor-I (IGF-I) levels in male and female athletes. Elite male athletes (n=5), female athletes (n=5) and healthy untrained young females (n=5) participated in this study. Isokinetic knee extensions were performed using the Biodex System 2 Isokinetic Dynamometer in athlete groups. Serum concentrations of DHEAS, testosterone, growth hormone (GH), IGF-I, IGF binding protein-3 (IGFBP-3), and cortisol were measured by radioimmunoassay (RIA). Bench press, leg press and peak torque/body mass (BM) were significantly (P<0.05) higher in male athletes than the female athletes. DHEAS was positively correlated with peak torque/BM (r=0.98, P<0.001) in female athletes. A negative correlation was found between peak torque/BW and testosterone (r=-0.94, P<0.001) in female athletes. In contrast, no statistically significant correlation coefficients were observed for muscle strength with anabolic hormone levels in male athletes. We demonstrated that DHEAS levels were correlated positively with leg extensor power in female athletes, but not in males. These findings suggest that blood level of DHEAS in female athletes indicate the important role of training-induced adaptation for muscular strength development.