Chemical and Biological Evaluation on Scopadulane-Type Diterpenoids from Scoparia dulcis of Vietnamese Origin
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概要
- 論文の詳細を見る
From the aerial parts of Scoparia dulcis L. (Scrophulariaceae) grown in Vietnam, four scopadulane-type diterpenoids (4-7), of which 7 is new and was given the trivial name scopadulcic acid C, together with nine known compounds were isolated. Their structures were elucidated by spectroscopic analyses. The absolute configurations of 4-7 were ascertained by applying the modified Mosher's method to iso-dulcinol (6). The isolation of the lignans nirtetralin and niranthin for the first time from S. dulcis is also of chemotaxonomic interest. The cytotoxic activity in KB cells, inhibitory effect on LPS/IFNγ-induced NO production, inhibition of multidrug resistance (MDR), and antibacterial and antifungal activities of the scopadulane-type diterpenoids 4-7 were examined in this study.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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Phan Minh
Faculty Of Chemistry College Of Natural Science Vietnam National University:graduate School Of Biome
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Matsunami Katsuyoshi
Graduate School of Biomedical Sciences, Hiroshima University
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Otsuka Hideaki
Department Of Pharmacognosy Graduate School Of Biomedical Sciences Hiroshima University
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Otsuka Hideaki
Dep. Of Pharmacognosy Graduate School Of Biomedical Sciences Hiroshima Univ.
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Otsuka H
Hiroshima Univ. Hiroshima Jpn
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PHAN Tong
Faculty of Chemistry, College of Natural Science, Vietnam National University
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Phan Tong
Faculty Of Chemistry College Of Natural Science Vietnam National University
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Matsunami Katsuyoshi
Dep. Of Pharmacognosy Graduate School Of Biomedical Sciences Hiroshima Univ.
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Matsunami Katsuyoshi
Graduate School of Biomedical and Health Sciences, Hiroshima University
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