Synthesis and Cytostatic Activity of 4,7-Dihydroxythioaurone Derivatives. Effect of B Ring Substitution on the Activity
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概要
- 論文の詳細を見る
Biological activity of thioaurones was not tested so far and the group constitute completely unexplored source of new molecules of pharmacological interest. We report synthesis and evaluation of cytotoxic activity of thioaurone derivatives bearing p-hydroquinone system in ring A. Their activity was found to depend strongly on substitution pattern, so eventually both the activity and pharmacokinetic parameters of the molecules could be tailored by further structural modifications.
- 社団法人日本薬学会の論文
- 2006-03-01
著者
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Wierzba Konstanty
Taiho Pharmaceutical Company Hanno Research Center
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Wierzba Konstanty
Taiho Pharmaceutical Co. Ltd. Hanno Research Center
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KONIECZNY Marek
Department of Organic Chemistry, Medical University of Gdansk
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KONIECZNY Wojciech
Department of Organic Chemistry, Medical University of Gdansk
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OKABE Soko
Taiho Pharmaceutical Company, Hanno Research Center
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TSUJIMOTO Hiroaki
Taiho Pharmaceutical Company, Hanno Research Center
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SUDA Yoshimitsu
Taiho Pharmaceutical Company, Hanno Research Center
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Okabe Soko
Taiho Pharmaceutical Company Hanno Research Center
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Konieczny Wojciech
Dep. Of Organic Chemistry Medical Univ. Of Gdansk
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Konieczny Marek
Dep. Of Organic Chemistry Medical Univ. Of Gdansk
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Konieczny Marek
Department Of Organic Chemistry Medical University Of Gdansk
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Konieczny Wojciech
Department Of Organic Chemistry Medical University Of Gdansk
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Suda Yoshimitsu
Taiho Pharmaceutical Company Hanno Research Center
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Tsujimoto Hiroaki
Taiho Pharmaceutical Company Hanno Research Center
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