Labeling of Acetaminophen with I-131 and Biodistribution in Rats

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概要

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• The aim of the present study was to label acetaminophen (APAP) with I-131 and to determine its radiopharmaceutical potential in rats. Acetaminophen was labeled with I-131 using the iodogen method. The radiochemical purity of ^<131>I-APAP was determined by RTLC and paper electrophoresis. The labeling yield was 94±4%. The biodistribution studies of the labeled compound (specific activity; 56.60 GBq/mmol) were performed in male Albino Wistar rats. The uptake of ^<131>I-APAP in some organs were determined at different time after injection to the rats. The radioactivity in each organ was counted and the percentage of injected activity per gram of tissue weight (%ID/g) for each organ and blood was calculated. ^<131>I-APAP uptake in the lung, liver, kidneys, pancreas, blood, stomach and some brain region, were observed. Thus, ^<131>I-APAP may be radiopharmaceutical for the imaging of the brain.

• 公益社団法人日本薬学会の論文
• 2006-02-01

著者

• Lambrecht Fatma

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• DURKAN Kubra

  Chemistry Program, Izmir Vocational School, Dokuz Eylul University

• YILDIRIM Yeliz

  Department of Chemistry, Faculty of Science, Ege University

• ACAR Cigdem

  Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University

• Durkan Kubra

  Chemistry Program Izmir Vocational School Dokuz Eylul University

• Yildirim Yeliz

  Department Of Chemistry Faculty Of Science Ege University

• Acar Cigdem

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• Yildim Yeliz

  Department of Chemistry, Faculty of Science, Ege University

関連論文

• Preparation of ^Tc Labeled Vitamin C (Ascorbic Acid) and Biodistribution in Rats
• Labeling of Acetaminophen with I-131 and Biodistribution in Rats
• Evaluation of ^Tc-labeled antibiotics for infection detection

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