Preparation of ^<99m>Tc Labeled Vitamin C (Ascorbic Acid) and Biodistribution in Rats

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概要

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• The aim of this study was to label ascorbic acid with ^<99m>Tc and to investigate its radiopharmaceutical potential in rats. Ascorbic acid was labeled with ^<99m>Tc using the stannous chloride method. The radiochemical purity of [^<99m>Tc] ascorbic acid (^<99m>Tc-AA) was determined by RTLC, paper electrophoresis, and RHPLC methods. The labeling yield was found to be 93±5.0%. The maximum labeling yield of ^<99m>Tc-AA was determined at pH 5 and 25℃. The biodistribution studies related to ^<99m>Tc-AA were done in male albino Wistar rats. ^<99m>Tc-AA, which has a specific activity of 13.02 GBq/mmol, was administered into the tail vein of the rats. The rats were sacrificed at 15, 30, 60, and 120min after the injection by heart puncture under ether anaesthesia. The organs were weighed after removal. Their activities were counted using a Cd(Te) detector equipped with a RAD 501 count system. The %ID/g (% of injected dose per gram of tissue weight) in each organ and in blood was calculated. Maximum uptake of ^<99m>Tc-AA was observed in prostate and kidneys at the 60th min. ^<99m>Tc-AA may be a promising radiopharmaceutical for the imaging of prostate and kidneys.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• Medine Emin

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• YIGIT Ugur

  Cigli High School

• LAMBRECHT Fatma

  Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University

• UNAK Perihan

  Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University

• BIBER Fazilet

  Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University

• CETINKAYA Berkan

  Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University

• Lambrecht Fatma

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• Unak Perihan

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• Biber Fazilet

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

• Cetinkaya Berkan

  Department Of Nuclear Applications Institute Of Nuclear Sciences Ege University

関連論文

• Preparation of ^Tc Labeled Vitamin C (Ascorbic Acid) and Biodistribution in Rats
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• Radiopharmaceutical model using ^Tc-MIBI to evaluate amifostine protection against doxorubicin cardiotoxicity in rats
• Evaluation of ^Tc-labeled antibiotics for infection detection

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