A Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Naphazoline and Antazoline in Eye Drops
スポンサーリンク
概要
- 論文の詳細を見る
A zero-crossing first-derivative spectrophotometric method is applied for the simultaneous determination of naphazoline hydrochloride and antazoline phosphate in eye drops. The measurements were carried out at wavelengths of 225 and 252nm for naphazoline hydrochloride and antazoline phosphate, respectively. The method was found to be linear (r^2>0.999) in the range of 0.2-1μg/ml for naphazoline hydrochloride in the presence of 5μg/ml antazoline phosphate at 225nm. The same linear correlation (r^2>0.999) was obtained in the range of 1-10μg/ml of antazoline phosphate in the presence of 0.5μg/ml of naphazoline hydrochloride at 252nm. The limit of determination was 0.2μg/ml and 1μg/ml for naphazoline hydrochloride and antazoline phosphate, respectively. The method was successfully used for simultaneous analysis of naphazoline hydrochloride and antazoline phosphate in eye drops without any interference from excipients and prior separation before analysis.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
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Souri Effat
Dep. Of Medicinal Chemistry Fac. Of Pharmacy And Pharmaceutical Sciences Res. Center Tehran Univ. Of
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Souri Effat
Department Of Medicinal Chemistry Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Me
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Farsam Hassan
Department Of Medicinal Chemistry Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Te
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Amanlou Massoud
Department Of Medicinal Chemistry Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Te
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AFSHARI Alma
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center,
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Afshari Alma
Department Of Medicinal Chemistry Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Te
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