EFFECT OF WHOLE BLOOD CLOTTING TIME IN RATS WITH IONIZED HYPOCALCEMIA INDUCED BY RAPID INTRAVENOUS CITRATE INFUSION
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概要
- 論文の詳細を見る
Although the toxic effects of citrate including hemodynamic and cardiovascular changes result from a decrease in ionized calcium levels in serum due to chelating action, these effects of citrate on blood coagulation have not yet been fully clarified. The present study examines whether serum citrate and ionized calcium levels affect whole blood clotting time in rats using the test tube method in which citrate is administered by rapid intravenous infusion. Citrate was infused via the tail vein into 10 rats at 3,4 or 5 mmol/kg/hr for 1 hr, and then whole blood clotting time, serum citrate and ionized calcium levels were determined. Whole blood clotting time did not significantly change at citrate infusion rates of 3 and 4 mmol/kg/hr. However, at 5 mmol/kg/hr, whole blood clotting time was significantly prolonged by a factor of 2.1 relative to the untreated group, when the serum citrate level was 10.03±1.39 mmol/1 (59.0-fold higher than that in the untreated group) and the serum-ionized calcium level was 0.29±0.02 mmol/1 (0.2-fold lower than that in the untreated group). These results suggest that whole blood clotting time is significantly prolonged in rats with severe ionized hypocalcemia.
- 日本トキシコロジー学会の論文
- 2006-08-23
著者
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Koshitani Osamu
大塚製薬工場
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Koshitani Osamu
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Koshitani Osamu
Division Of Drug Safety Evaluation Naruto Res.inst. Otsuka Pharmaceutical Factory Inc.
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Koshitani Osamu
大塚製薬
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Kawaguchi Yoshiro
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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TOYOSHIMA Shigeki
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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HARADA Miwa
Division of Pharmacology, Drug Safety and Metabolism, Olsuka Pharmaceutical Factory, Inc.
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NAKASHIMA Yoshifumi
Division of Pharmacology, Drug Safety and Metabolism, Olsuka Pharmaceutical Factory, Inc.
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FUKUDA Tatsuru
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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NAKAYAMA Mitsuo
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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KAWAUCHI YOSHIYUKI
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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Kawauchi Yoshiyuki
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nakayama Mitsuo
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Harada M
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Fukuda Tatsuru
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nakayama Mitsuo
Div. Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Toyoshima Shigeki
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nakashima Yoshifumi
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Nakashima Yoshifumi
Division Of Pharmacology Drug Safety And Metabolism Olsuka Pharmaceutical Factory Inc.
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Nakashima Yoshifumi
Division of Nanomaterials Science, EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
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