エリスロマイシンとLactococcus garvieae感染症ワクチンの投与がブリのL. garvieae感染症の発生動向と原因菌の薬剤感受性に及ぼす影響

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Influence of treatment with erythromycin (EM) and vaccine for Lactococcus garvieae infection in cultured yellowtail Seriola qunqueradiata on the drug resistance of L. garvieae and occurrence of this disease were studied. L. garvieae infection in yellowtail has been one of the most serious recent disease problems in Azumacho Fisheries Cooperative Association which has achieved the largest production of cultured yellowtail in Japan. Control of the infection with erythromycin increased the number of resistant strains of L. garvieae and following the drug withdrawal period in winter allowed for the recovery of sensitivity to EM. Since occurrence of the infection was not reduced during an oral vaccination period from 1997 to 2000, the oral vaccine was not widely used because of its poor performance. L. garvieae infection has been remarkably reduced by the injection of a new vaccine that has been available commercially since 2001. Only a few strains of L. garvieae were still isolated from the diseased fish which had not been vaccinated and those isolates showed resistance against EM because the drug had been administered to their host fish. We conclude that L. garvieae infection in cultured yellowtail has been effectively controlled by the injection vaccine in Azumacho Fisheries Cooperative Association.
2005-12-27