Effects of Possible Endocrine Disrupting Chemicals on Bacterial Component-Induced Activation of NF-κB(Microbiology)

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概要

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• Endocrine disrupting chemicals (EDCs) have a possibility to exacerbate infectious diseases because EDCs disturb the human immune system by interfering with endocrine balance. To assess the influence ofEDCs on the innate immune function of macrophages, we investigated the effects of thirty-seven possible endocrine disrupters on lipopolysaccharide (LPS)- or bacterial lipopeptide (Pam_3CSK_4)-induced activation of nuclear factor kappa B (NF-κB). Alachlor, benomyl, bisphenol A, carbaryl, kelthane, kepone, octachlorostyrene, pentachlorophenol, nonyl phenol, p-octylphenol and ziram inhibited both LPS- and Pam_3CSK_4-induced activation of NF-κB. Simazine inhibited only LPS-induced activation. A strong inhibitory effect was observed with ziram and benomyl. On the other hand, diethylhexyl adipate and 4-nitrotoluene tended to enhance the activation induced by Pam_3CSK_4 and LPS, respectively. Aldicarb, amitrole, atrazine, benzophenone, butyl benzyl phthalate, 2,4-dichlorophenoxy acetic acid, dibutyl phthalate, 2,4-dichlorophenol, dicyclohexyl phthalate, diethylhexyl phthalate, diethyl phthalate, dihexyl phthalate, di-n-pentyl phthalate, dipropyl phthalate, malathion, methomyl, methoxychlor, metribuzin, nitrofen, permethrin, trifluralin, 2,4,5-trichlorophenoxyacetic acid and vinclozolin had no significant effects at 100μM. These results indicate that some agrochemicals have the potential to inhibit macrophage function and suggest that endocrine disrupters may influence the development of bacterial infections.

• 公益社団法人日本薬学会の論文
• 2006-10-01

著者

• Muroi Masashi

  Division Of Microbiology National Institute Of Health Sciences

• Tanamoto Ken-ichi

  Division of Micro biology and Immunochemistry, National Institute of Health Sciences

• IGARASHI Arisa

  Division of Microbiology, National Institute of Health Sciences

• OHTSU Satoko

  Division of Microbiology, National Institute of Health Sciences

• Ohtsu Satoko

  Division Of Microbiology National Institute Of Health Sciences

• Igarashi Arisa

  Division Of Microbiology National Institute Of Health Sciences

• Tanamoto Ken-ichi

  Res. Inst. Of Pharmaceutical Sciences Musashino Univ.

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• Effect of Endocrine Disrupting Chemicals on Lipopolysaccharide-Induced Tumor Necrosis Factor-α and Nitric Oxide Production by Mouse Macrophages(Toxicology)
• Effects of Possible Endocrine Disrupting Chemicals on Bacterial Component-Induced Activation of NF-κB(Microbiology)
• Inhibitory effects of soluble MD-2 and soluble CD14 on bacterial growth

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