Decreased Levels of Liver alpha-Tocopherol and Plasma Insulin by Feeding Doxycycline

概要

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Tetracyclines are widely used not only as antibiotics for the treatment of infectious diseases, but also as the food additives for farming animals. They have been considered to have few serious adverse effects. Here we report the difference in induction of methemoglobin formation among six members of tetracyclines family (tetracycline, chlortetracycline, demecrocycline, doxycycline, minocycline, oxytetracycline), when incubated with human hemolysates. The results showed that addition of doxycycline to human hemolysates had the strongest effect on induction of methemoglobin formation. We also found that 0.6% of doxycycline feeding to rats for 4 weeks caused significant reduction of liver alpha-tocopherol concentration and alpha-tocopherol/polyunsaturated fatty acid ratio, plasma triacyglycerol and insulin level. The glucose, cholesterol, HDL-cholesterol and phospholipid concentrations in blood, however, were increased. These results suggest that doxycycline in human hemolysates might undergo oxidation leading to induction of methemoglobin formation and insulin cells, as well as liver in the doxycycline-fed rats probably suffered higher oxidative damage.
くらしき作陽大学の論文
2005-12-28