Comparison of Body Fat Distribution and Blood Lipid Profiles according to Trp64Arg Polymorphism for the β_3-Adrenergic Receptor Gene in Korean Middle-Aged Women

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概要

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• The aim of this study was to determine whether there was an association between body fat distribution, blood lipid profiles, and β_3-adrenergic receptor gene polymorphism in Korean middle-aged women. Subjects were grouped according to BMI as obese (≥25 BMI, n=95) or non-obese (BMI<25, n=93). The Trp64Arg mutation of the β_3-adrenergic receptor gene was detected by PCR-RFLP. Skinfold thickness, body circumference, intra-abdominal fat area by CT, and blood lipid profiles were also measured. Data were compared using ANOVA, Bonferroni t-test, and Chi-square. Significance for statistical analyses were set at p<0.05. In the obese group, 63.16% were Trp64Trp homozygotes and 36.84% were Trp64Arg heterozygotes, compared to 80.65% who were Trp64Trp homozygotes and 19.35% who were Trp64Arg heterozygotes in the non-obese group. These results indicated a significant (χ^2=4.943, p<0.05) difference between the two groups. Frequency of the Arg64 allele in the obese group (16.84%) showed a significant χ^2=4.185, p<0.05) difference as compared to the non-obese group (9.68%). Skinfold thickness and body circumference of the Trp64Arg heterozygote group showed a consistent increase as compared to the Trp64Trp homozygote group. Visceral fat area and VSR of Trp64Arg heterozygote group showed a higher tendency than Trp64Trp homozygotes in the obese group, but these differences were not statistically significant. In conclusion, the Trp64Arg polymorphism of the β_3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the β_3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.

• 日本ビタミン学会の論文

著者

• Kim Kijin

  Department of Physical Education, College of Physical Education, Keimyung University

• Ahn Nayoung

  Department of Physical Education, College of Physical Education, Keimyung University

• Hong Changbae

  Department of Physical Education, College of Physical Education, Keimyung University

• Kim Sanghyun

  Department of Physical Education, College of Physical Education, Keimyung University

• Shin Yoonjung

  Department of Physical Education, College of Physical Education, Keimyung University

• Kim Kijin

  Department Of Physical Education College Of Physical Education Keimyung University

• Ahn Nayoung

  Department Of Physical Education College Of Physical Education Keimyung University

• Kim Sanghyun

  Department Of Physical Education College Of Physical Education Keimyung University

• Kim Sanghyun

  Department Of Electrical Engineering Gyeongsang University

• Shin Yoonjung

  Department Of Physical Education College Of Physical Education Keimyung University

• Hong Changbae

  Department Of Physical Education College Of Physical Education Keimyung University

• LIM Kiwon

  Department of Physical Education, Konkuk University

• Lim Kiwon

  Department Of Physical Education Konkuk University

• LEE Seungno

  Department of Physical Education, Keimyung University

• LEE Sunjang

  Department of Physical Education, Keimyung University

• CHEUN Wookwang

  Department of Physical Education, Keimyung University

• PARK Jusik

  School of Sports for All, Gyeongju University

• Lee Seungno

  Department Of Physical Education Keimyung University

• Park Jusik

  School Of Sports For All Gyeongju University

• Cheun Wookwang

  Department Of Physical Education Keimyung University

• LIM Kiwon

  Department of Athletics, School of Art & Athletics, University of Inchon

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