前立腺癌アンドロゲン抑制療法に伴うホルモン環境ならびに前立腺局所の変化

概要

論文の詳細を見る
Androgen deprivation therapy (ADT) is a hormonal therapy to suppress the effects of androgen secreted from the testis and/or the adrenal gland in the patients with prostate cancer. Dihydrotestosterone (DHT) level in prostatic tissues under ADT is not clearly known. The influence of ADT on the volume of anatomic zones of the prostate and the tissue component have not yet been clarified. We studied changes in DHT level in prostatic tissues during ADT for prostate cancer. We also analyzed the influence of ADT on the volume of anatomic zones for prostate cancer arising in and localizing in the peripheral zone and the tissue component using MRI. DHT level in prostatic tissues remained at about 25% of pre-treatment level after ADT. When anti-androgens were combined with testicular suppression, they can block stimulation from adrenal androgens that contribute approximately 25% of total DHT. The volumes after ADT in the whole prostate, transition zone, and peripheral zone were significantly smaller than the volumes before ADT. The present results revealed that not only the epithelial region in the transition zone but also the stromal region was sensitive to androgen and the volume of the transition zone was reduced during ADT regardless of its histological components.
新潟大学の論文
2004-04-10