子宮運動に対する非特異ヒアルロニダーゼ抑制物質の役割について
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概要
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1. The nonspecific hyaluronidase inhibitor (NSHI) in the pregnant rabbit's serum remained almost constant during pregnancy, but showed a marked increase between the 3rd and 4th days prepartum and reached a peak the 2nd day after the parturition, returning to the normal level within 5 to 7 days postpartum. 2. The administration of progesterone caused a decrease of NSHI in the castrated male rabbit's serum. 3. Artiflcial abortion of the pregnant rabbits at 23th day increased NSHI levels at the 2nd day, reached maximum values between 3rd and 4th days and returned to normal the 8th-9th days after the operation. 4. The serum of higher NSHI level stimulated the isolated rat's uterus more strongly than that of lower level in Tyrode's solution. The stimulating effect of serum on uterine motility is significantly associated with the degrees of NSHI levels. 5. NSHI inactivated serum by heating had no accelerating effect or inhibiting effect on the uterine motility. 6. The oxytocic substance in the serum which is highly associatiated with NSHI differs from oxytocin in the posterior lobe of pituitary. 7. The possible role of NSHI in the serum at parturition is discussed.
- 大阪府立大学の論文
- 1955-12-25
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