ラット血清中の非特異性ヒアルロニダーゼ抑制物質に対するステロイドホルモンの影響
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概要
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1. The viscosimetric technique for the measurement of hyaluronidase inhibitor in the serum was decribed and effects of several steroid hormones on the nonspecific hyaluronidase inhibitor (NSHI) levels in rats' sera have been studied. 2. NSHI levels and the weights of adrenals per 100g of body weight in the normal male rats showed a drastic change between 30 and 35 days of age and these two measurements showed a significant negative correlationship. 3. Under the formalin stress, NSHI levels, adrenal weights and thymus weights decreased and blood sugar increased synchroneously during the first 12 hours and these values returned to the normal levels until 24 hours after the initiation of the stress. And NSHI levels and adrenals weight continued to increasing thereafter. NSHI concentrations and adrenal weights per 100g of body weight showed a significant positive correlationship. 4. Diethylstilbestrol injection decreased NSHI levels in sera of gonadectomized rats. But it has no effect on NSHI of the adrenal-gonadectomized and hypophys-gonadectomized rats. 5. Progesterone admistration decreased NSHI levels in sera of gonadectomized rats, and changed the inhibitor levels of adrenal-gonadectomized rats without definite tendency. 6. Testosterone propionate treatment induced the decrease of NSHI levels in the gonadectomized rats' sera, and it changed NSHI levels of adrenal-gonadectomized rats and hypophys-gonadectomized rats showing a significant differences of variances in contrast with controls.
- 大阪府立大学の論文
- 1955-12-25
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- ラット血清中の非特異性ヒアルロニダーゼ抑制物質に対するステロイドホルモンの影響