Expression Changes of ERK1/2, STAT3 and SHP-2 in Bone Marrow Cells from γ-ray Induced Leukemia Mice
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概要
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The aim is to clarify expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from γ-ray induced leukemia mice. A mouse model of γ-ray induced leukemia was produced, and by means of quantitative real-time PCR, immunoprecipitation, Western blotting and electrophoretic mobility shift assays (EMSA), the expression of mRNA and protein, phosphorylation level, and protein activity of ERK1/2, STAT3 and SHP-2 in bone marrow cells were investigated in these mice. The results indicated that mRNA and protein expressions of ERK1/2 were upregulated, with significant increase of phosphorylation level and protein activity, but with insignificant differences in mRNA and protein expressions, phosphorylation level and protein activity of STAT3 and SHP-2 in bone marrow cells from γ-ray induced leukemia mice compared to the radiation/tumor-free or control mice. It is concluded that in the pathogenesis of γ-ray induced leukemia in Balb/C mice, activated ERK1/2 pathway may play a role, without involving STAT3 pathway; meanwhile, SHP-2 exerts no regulative effect on pathways of Ras-ERK1/2 and JAK-STAT.
- 日本放射線影響学会の論文
- 2006-06-30
著者
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CAI Jianming
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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Cai Jianming
Department Of Radiology Faculty Of Navy Medicine Second Military Medical University
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CHEN Qi
Department of Pathology, Fudan University
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Chen Qi
Department Of Neuropathology Medical Research Institute Tokyo Medical And Dental University
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Chen Qi
Department Of Radiology Faculty Of Navy Medicine Second Military Medical University
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FU Zhichao
Department of Radiotherapy, General Hospital of Fuzhou Military Command
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HUANG Dingde
Department of Nuclear Medicine, Southwest Hospital, Third Military Medical University
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HAN Ling
Department of Radiology, Faculty of Navy Medicine, Second Military Medical University
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LI Bailong
Department of Radiology, Faculty of Navy Medicine, Second Military Medical University
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WANG Fengmei
Department of Histology and Embryology, School of Basic Medicine, Second Military Medical University
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GAO Jianguo
Department of Radiology, Faculty of Navy Medicine, Second Military Medical University
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Cai Jianming
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Han Ling
Department Of Radiology Faculty Of Navy Medicine Second Military Medical University
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Li Bailong
Department Of Radiology Faculty Of Navy Medicine Second Military Medical University
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Fu Zhichao
Department Of Radiotherapy General Hospital Of Fuzhou Military Command
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Gao Jianguo
Department Of Radiology Faculty Of Navy Medicine Second Military Medical University
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Wang Fengmei
Department Of Histology And Embryology School Of Basic Medicine Second Military Medical University
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Huang Dingde
Department Of Nuclear Medicine Southwest Hospital Third Military Medical University
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Li Bailong
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Chen Qi
Department Of Neurology Yantai Yuhuangding Hospital
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