The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice
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概要
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Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.
- 2010-11-16
著者
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Qian Liren
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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Cao Fei
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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Cui Jianguo
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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WANG Yicun
Department Of Orthopaedics, Changhai Hospital
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HUANG Yuecheng
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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CHUAI Yunhai
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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ZAHO Luqian
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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JIANG Hao
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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CAI Jianming
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University
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Jiang Hao
Department Of Mathematics Xixi Campus Of Zhejiang University
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Chuai Yunhai
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Huang Yuecheng
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Cao Fei
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Zaho Luqian
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Cai Jianming
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Cui Jianguo
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Qian Liren
Department Of Radiation Medicine Faculty Of Naval Medicine Second Military Medical University
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Wang Yicun
Department Of Orthopaedics Changhai Hospital
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Jiang Hao
Department Of Bioprocess Development
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- The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice
- The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice
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