The Wisconsin card sorting test performance and the P300 of event-related potentials in schizophrenia

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Both a poor performance on the Wisconsin Card Sorting Test (WCST) and abnormalities in P300 are the most frequently replicated biological findings in schizophrenic patients. The relationships between the computer version of WCST performance and the P300 amplitude and latency were examined in 36 schizophrenic patients. Event-related potentials were recorded during two auditory tasks, which were a standard oddball task and a distraction task similar to that of Grillon et al. (1990). Several of the WCST performance measures correlated significantly with P300 latency for the target stimuli in both tasks. When dividing the patients into the good WCST group and the poor WCST group, there was a significant difference in the P300 latency for the target stimuli in the distraction task and an altered P300 distribution for the target stimuli in the oddball task for the novel stimuli in the distraction task between the two groups. These findings indicated that impaired frontal lobe function might cause a delay in information processing in schizophrenia.