Ontogeny of Amino Acids Related to Excitatory Amino Acidergic Transmission in the Rat Forebrain

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概要

• 論文の詳細を見る

• Developmental changes in the concentration of putative amino acid neurotrsansmitters were investigated in the forebrain of prenatal and postnatal rats. Glutamate and aspartate, which interact with three-typed agonist sites of excitatory amino acid receptors, decreased until birth and then increased with maturation. Agonists for strychnine-insensitive glycine sites, i.e., glycine, serine and alanine, showed progressive decreases in the postnatal period. Although alanine rapidly decreased in preterm, there was no change in glycine and serine contents in this period. These developmental patterns of the compounds related to EAA transmission differed from those of inhibitory amino acid transmitters. GABA showed a steady increase during ontogeny. Taurine increased until birth and then decreased to the adult level. These results suggested that the ontogenic profile for EAA is different from that for the glycine receptor agonists and that other inhibitory amino acid transmitters develop with patterns different from those of amino acids related to EAAergic transmission.

• 東海大学の論文

著者

• Shinohara Kazuyuki

  Division Of Mental Disorder Research National Institute Of Neuroscience Ncnp:department Of Psychiatr

• YAMAZAKI Kosuke

  Department of Psychiatry, Course of Specialized Clinical Science, Tokai University School of Medicin

• Nishikawa Toru

  Division Of Mental Disorder Research National Institute Of Neuroscience Ncnp

• ISHII Sumikazu

  National Center Hospital for Mental, Nervous and Muscular Disease, NCNP, Tokyo, Japan

• TAKAHASHI Kiyohisa

  Division of Mental Disorder Research, National Institute of Neuroscience

• Ishii Sumikazu

  National Center Hospital For Mental Nervous And Muscular Disease Ncnp Tokyo Japan

• Ishii Sumikazu

  National Center For Nervous Mental And Muscular Disorders

• Takahashi Kiyohisa

  Division Of Mental Disorder Research National Institute Of Neuroscience Ncnp

• Yamazaki Kosuke

  Department Of Psychiatry And Behavioral Science School Of Medicine Tokai University

• Yamazaki Kosuke

  Department Of Psychiatry School Of Medicine Tokai University Isehara Japan

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