Biochemical Properties of Pertussis Toxin(I. Characterization of Virulence Factors of Bordetella pertussis)(Current Studies on Future Vaccines)
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概要
- 論文の詳細を見る
Pertussis toxin is an exotoxin produced by the organism Bordetella pertussis. The toxin binds to receptors on the eukaryotic cell surface. After introduction into the eukaryotic cell, the toxin is activated by ATP and subsequently ADP-ribosylates a family of GTP-binding regulatory proteins interrupting signal transduction within the cell. We have examined the location of several critical sites on the toxin molecule. These sites include the receptor binding site and the ATP binding site. The B oligomer of the toxin was found to contain at least two sites capable of binding glycoproteins suggesting that the B oligomer may have more than one eukaryotic cell receptor binding site. ATP was also shown to bind to a site on the B oligomer. These results indicate that the B oligomer contains several sites necessary for toxin action.
- 東海大学の論文
- 1988-09-22
著者
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Brennan Michael
Laboratory Of Pertussis Center For Biologics Evaluation And Research Food And Drug Administration
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BURNS Drusilla
Laboratory of Pertussis, Center for Biologics Evaluation and Research, Food and Drug Administration
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HAUSMAN Sally
Laboratory of Pertussis, Center for Biologics Evaluation and Research, Food and Drug Administration
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WITVLIET Maarten
Laboratory of Bacterial Vaccines, National Institute for Public Health and Environmental Protection
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POOLMAN Jan
Laboratory of Bacterial Vaccines, National Institute for Public Health and Environmental Protection
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MANCLARK Charles
Laboratory of Pertussis, Center for Biologics Evaluation and Research, Food and Drug Administration
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Poolman Jan
Laboratory Of Bacterial Vaccines National Institute For Public Health And Environmental Protection
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Hausman Sally
Laboratory Of Pertussis Center For Biologics Evaluation And Research Food And Drug Administration
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Burns Drusilla
Laboratory Of Pertussis Center For Biologics Evaluation And Research Food And Drug Administration
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Witvliet Maarten
Laboratory Of Bacterial Vaccines National Institute For Public Health And Environmental Protection
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Manclark Charles
Food And Drug Administration
関連論文
- Structural and Functional Properties of a 69-Kilodalton Outer Membrane Protein of Bordetella pertussis(I. Characterization of Virulence Factors of Bordetella pertussis)(Current Studies on Future Vaccines)
- Biochemical Properties of Pertussis Toxin(I. Characterization of Virulence Factors of Bordetella pertussis)(Current Studies on Future Vaccines)
- Outbreaks of Pertussis in the United States : The Wisconsin Experience(B. Vaccine Schedules: Their Pelationship to Current Epidemiology)(II. The Eradication of Pertussis: Current Unsolved Epidemiologic, Clinical and Public Health Problems which Impede Thi