The Respiratory Burst of Granulocytes: Modulation by Inflammatory Mediators and Its Mechanism
スポンサーリンク
概要
- 論文の詳細を見る
Prior exposure of granulocytes to inflammatory mediators such as chemotactic factors, colonystimulating factors and tumor necrosis factor primes the cells for enhanced activity of the respiratory burst, which appears not only to play an essential role in the increased host-defenses against invading microorganisms but also to be responsible for tissue damage at the inflammatory sites. The molecular basis for this priming is presently under investigation. Changes in one or more of the signal transduction events may lead to more efficient stimulation of the NADPH oxidase responsible for the respiratory burst. The mechanisms of priming appear to be different according to the priming stimuli: the chemotactic peptide and the Ca^<2+> ionophore may prime the cells by causing an increase in cytoplasmic free Ca^<2+>; phorbol esters by activating protein kinase C; and colonystimulating factors and tumor necrosis factor by activating the distinct mechanism, which is independent of an increase in cytoplasmic free Ca^<2+> and activation of protein kinase C.
- 東海大学の論文
- 1988-03-17
著者
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Takaku Fumimaro
Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Saito Masaki
Division Of Hepatobiliary And Pancreatic Diseases Department Of Internal Medicine Hyogo College Of M
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KITAGAWA Seiichi
Division of Hemopoiesis, Institute of Hematology
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Yuo Akira
Division Of Hemopoiesis Institute Of Hematology And Department Of Medicine Jichi Medical School
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Takaku Fumimaro
Third Department Of Internal Medicine Faculty Of Medicine Tokyo University
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Ohsaka Akimichi
Division Of Hemopoiesis Institute Of Hematology And Department Of Medicine Jichi Medical School
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Saito M
Sony Co.
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Kitagawa S
Division Of Hemopoiesis Institute Of Hematology And Department Of Medicine Jichi Medical School
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Kitagawa Seiichi
Division Of Hemopoiesis Institute Of Hematology
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Saito Masaki
Division Of Hemopoiesis Institute Of Hematology And Department Of Medicine Jichi Medical School
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