Platelet-derived Endothelial Cell Growth factor : Structure and Function : 54th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45-kDa single chain polypeptide, which stimulates the growth and chemotaxis of endothelial cells in vitro and angiogenesis in vivo. Purification from human platelets and cDNA cloning of PD-ECGF disclosed that it is a novel type of angiogenic factor without sequence similarity to hitherto known proteins. PD-ECGF is present in human platelets as well as in placenta. Amino acid sequencing of PD-ECGF from human placenta revealed that the placental form has an additional 5 amino acids at the N-terminus. In cultured cells. it is produced by normal fibroblasts as well as some transformed cell lines. PD-ECGF lacks a hydrophobic signal sequence and remains inside the producer cells. PD-ECGF may act at sites of injuty as a wound hormone and thus play an important role under several physiological and pathological conditions.
- 社団法人日本循環器学会の論文
- 1991-10-20
著者
-
Takaku Fumimaro
Third Department Of Internal Medicine Faculty Of Medicine Tokyo University
-
MIYAZONO KOHEI
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
Miyazono Kohei
Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
-
TAKAKU Fumimaro
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
関連論文
- 8)DISTINCTIVE PATTERNS OF MYOSIN ISOZYMES IN THE CONDUCTION SYSTEM AND ABNORMAL MUSCLE BUNDLES OF HUMAN HEARTS : THE 7th CONFERENCE ON CARDIOMYOPATHY
- A NEW METHOD OF IMAGES OF MYOCARDIAL INFARCTION WITH LABELLED MONOCLONAL ANTIBODY SPECIFIC FOR VENTRICULAR MYOSIN HEAVY CHAIN : Nuclear Cardiology (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- -0647-EXPRESSION OF PERFORIN IN ASIALO GM1^+ INFILTRATING CELLS IN MURINE HEART WITH ACUTE VIRAL MYOCARDITIS
- -0072-THE MOLECULAR MECHANISM OF STRETCH INDUCED CARDIAC HYPERTROPHY
- -0067-THE MOLECULAR MECHANISM OF ANGIOTENSIN II INDUCED C-FOS GENE EXPRESSION ON CARDIOMYOCYTES
- Mechanisms of Cardiac Hypertrophy and Injury : Possible Role of Protein Kinase C Activation : 54th Annual Scientific Session of the Japanese Circulation Society
- The Respiratory Burst of Granulocytes: Modulation by Inflammatory Mediators and Its Mechanism
- Platelet-derived Endothelial Cell Growth factor : Structure and Function : 54th Annual Scientific Session of the Japanese Circulation Society
- Outline of Clinical Studies on Recombinant Human Granulocyte Colony Stimulating Factor (KRN 8601) in Japan
- PC75 SYNTHESIS OF DOLICHOLS AND EFFECT OF EXOGENOUS ADDITION OF DOLICOLS INTO HEMATOPOIETIC SYSTEMS
- A Case of Congenital Aneurysm of the Pulmonary Artery
- A case of Takayasu's disease with ruptured carotid aneurysm.
- Mechanism of polyuria and natriuresis associated with paroxysmal supraventricular tachycardia.