SIMPLE SEPARATION OF THE BUFADIENOLIDE DERIVATIVES AND ISOMERS BY THE HYDROPHOBIC GEL SEPHADEX LH-20

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概要

• 論文の詳細を見る

• We have examined the column chromatography using hydrophobic gel, Sephadex LH-20,for separation of the derivatives and isomers of the bufadienolide; bufalin, cinobufagin, and resibufogenin. The use of n-hexane/CH_2Cl_2/MeOH(4 : 5 : 1) and n-hexane/EtOAc/MeOH(4 : 5 : 1) as developing solvents provides the effective separation of the bufadienolide derivatives such as 3-ester, 3-oxo, Δ^4,and Δ^<1,4> derivatives and isomers at 14-position. By this study with previous separation for natural bufadienolides, the use of hydrophobic gel was found to be useful in the point of less-energy and economic aspect, besides the good separation.

• 神奈川大学の論文

著者

• Yamashita Ayano

  Faculty of Science, Kanagawa University

• Nogawa Toshihiko

  Faculty of Science, Kanagawa University

• Kamano Yoshiaki

  Faculty Of Science Kanagawa University

• Yamashita Ayano

  Faculty Of Science Kanagawa University

• Nogawa Toshihiko

  Faculty Of Science Kanagawa University

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• SIMPLE SEPARATION OF THE BUFADIENOLIDE DERIVATIVES AND ISOMERS BY THE HYDROPHOBIC GEL SEPHADEX LH-20

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